Clinically, amitriptyline is used to treat depression, pain of neuropathic origin, attention-deficit hyperactivity disorder, functional enuresis in children, panic disorder, and phobic disorder, and to manage some eating disorders. CLINICAL PHARMACOLOGY Mechanism of Action: The precise action of tricyclic antidepressants is not fully understood, but it is believed that the most important effect is the decreased reuptake of norepinephrine and serotonin.
Amitriptyline appears to exert effects on both norepinephrine and serotonin (5-HT), although the selective-acting desipramine is a more potent inhibitor of norepinephrine transport.
Symptomatic and prophylactic treatment of migraine and tension-type headache. [amitriptyline dosage, atenolol dosage, chlorpromazine dosage, cyproheptadine dosage, dexamethasone dosage, diflunisal dosage, diltiazem dosage, doxepin dosage, fluoxetine dosage, haloperidol dosage, ibuprofen dosage, indomethacin dosage, ketoprofen dosage, meclofenamate, mefenamic acid dosage, meperidine dosage, morphine dosage, nadolol dosage, naproxen dosage, nifedipine dosage, nimodipine dosage, nortriptyline dosage, phenelzine dosage, phenytoin dosage, piroxicam dosage, prednisone dosage, propranolol dosage, sulindac dosage, timolol dosage, verapamil dosage, -blockers overview] DESCRIPTION Amitriptyline is an oral and parenteral tertiary amine tricyclic antidepressant.
It is structurally related to the thioxanthene antipsychotics such as thiothixene.
It's generic, so it's considerably cheaper than many of the other widely prescribed sleep medications—about for a week's supply.
That's compared to other sleep drugs like generic zolpidem (Ambien), generic eszopiclone (Lunesta) or generic Sonata (zalepon) that run about for a week's supply.
This means that if you take Effexor, your body breaks it down into Pristiq and other chemicals. For this reason, some people say Pristiq is nothing but a “patent extender”. But what I think can’t be argued is the fact Pristiq has to, by definition, have fewer side effects on the whole than Effexor.
Moreover, many doctors seem to believe that trazodone is less likely than even the newer sleep drugs to cause dependency and, when discontinued, renewed insomnia.The down-regulation of limbic beta-receptors that results from this synaptic neurotransmitter increase occurs ~57 days after therapeutic concentrations are reached.Monoamine oxidase is not inhibited by either amitriptyline or nortriptyline.It’s been just over twenty-five years since Prozac came to market, and more than twenty per cent of Americans now regularly take mind-altering drugs prescribed by their doctors.Almost as familiar as brands like Zoloft and Lexapro is the worry about what it means that the daily routine in many households, for parents and children alike, includes a dose of medications that are poorly understood and whose long-term effects on the body are unknown. “We are facing a crisis,” the Cornell psychiatrist and New York contributor Richard Friedman warned last week.